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Books

Molecular Biology


Essential Cell Biology

Essential Cell Biology Lowest new price: $44.99
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List price: $159.00
Author: Bruce Alberts
Brand: Brand: Garland Science

Essential Cell Biology provides an accessible introduction to the fundamental concepts of cell biology. Its lively writing and exceptional illustrations make it the ideal textbook for a first course in cell and molecular biology. The text and figures are easy-to-follow, accurate, clear, and engaging for the introductory student. Molecular detail has been kept to a minimum in order to provide the reader with a cohesive, conceptual framework of the basic science that underlies our current understanding of biology.

The Third Edition is thoroughly updated scientifically, yet maintains the academic level and size of the previous edition. The book is accompanied by a Media DVD-ROM with over 130 animations and videos, all the figures from the book, and a new self-test quizzing feature for students.

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Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids

Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids Lowest new price: $39.98
Lowest used price: $19.49
List price: $50.00
Author: Richard Durbin
Brand: Brand: Cambridge University Press

Probablistic models are becoming increasingly important in analyzing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analyzing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it is accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time presents the state of the art in this new and important field.

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Fly Pushing: The Theory and Practice of Drosophila Genetics

Fly Pushing: The Theory and Practice of Drosophila Genetics Lowest new price: $46.71
Lowest used price: $57.25
List price: $61.00
Author: Ralph J Greenspan

A second edition of the classic handbook has become a standard in the Drosophila field. This edition is expanded to include topics in which classical genetic strategies have been augmented with new molecular tools. Included are such new techniques as homologous recombination, RNAi, new mapping techniques, and new mosaic marking techniques.

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Bioinformatics: Sequence and Genome Analysis

Bioinformatics: Sequence and Genome Analysis Lowest new price: $54.95
Lowest used price: $35.14
List price: $95.00
Author: David Mount
Brand: Brand: Cold Spring Harbor Laboratory Press

As more species' genomes are sequenced, computational analysis of these data has become increasingly important. The second, entirely updated edition of this widely praised textbook provides a comprehensive and critical examination of the computational methods needed for analyzing DNA, RNA, and protein data, as well as genomes. The book has been rewritten to make it more accessible to a wider audience, including advanced undergraduate and graduate students. New features include chapter guides and explanatory information panels and glossary terms. New chapters in this second edition cover statistical analysis of sequence alignments, computer programming for bioinformatics, and data management and mining. Practically oriented problems at the ends of chapters enhance the value of the book as a teaching resource. The book also serves as an essential reference for professionals in molecular biology, pharmaceutical, and genome laboratories.

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Beginning Perl for Bioinformatics

Beginning Perl for Bioinformatics Lowest new price: $18.97
Lowest used price: $6.06
List price: $39.95
Author: James Tisdall

With its highly developed capacity to detect patterns in data, Perl has become one of the most popular languages for biological data analysis. But if you're a biologist with little or no programming experience, starting out in Perl can be a challenge. Many biologists have a difficult time learning how to apply the language to bioinformatics. The most popular Perl programming books are often too theoretical and too focused on computer science for a non-programming biologist who needs to solve very specific problems.

Beginning Perl for Bioinformatics is designed to get you quickly over the Perl language barrier by approaching programming as an important new laboratory skill, revealing Perl programs and techniques that are immediately useful in the lab. Each chapter focuses on solving a particular bioinformatics problem or class of problems, starting with the simplest and increasing in complexity as the book progresses. Each chapter includes programming exercises and teaches bioinformatics by showing and modifying programs that deal with various kinds of practical biological problems. By the end of the book you'll have a solid understanding of Perl basics, a collection of programs for such tasks as parsing BLAST and GenBank, and the skills to take on more advanced bioinformatics programming. Some of the later chapters focus in greater detail on specific bioinformatics topics. This book is suitable for use as a classroom textbook, for self-study, and as a reference.

The book covers:

  • Programming basics and working with DNA sequences and strings
  • Debugging your code
  • Simulating gene mutations using random number generators
  • Regular expressions and finding motifs in data
  • Arrays, hashes, and relational databases
  • Regular expressions and restriction maps
  • Using Perl to parse PDB records, annotations in GenBank, and BLAST output

Biology, it seems, is a good showcase for the talents of Perl. Newcomers to Perl who understand biological information will find James Tisdall's Beginning Perl for Bioinformatics to be an excellent compendium of examples. Teachers of Perl will likewise find the text to be filled with fresh programming illustrations of growing scientific importance. Seasoned Perlmongers who want to learn biology, however, should search elsewhere, as Tisdall's emphasis is on Perl's logic rather than Mother Nature's.

Departing from O'Reilly's earlier monograph Developing Bioinformatic Computer Skills, Tisdall's text is organized aggressively along didactic lines. Nearly all of the 13 chapters begin with twin bullet lists of Perl programming tools and the bioinformatic methods that require them. Likewise, the chapters end with exercises. String concatenation is illustrated with gene splicing, and regular expressions are taught with gene transcription and motif searching.

Tisdall emphasizes sequence examples throughout, leading up to an introduction to a Perl interface for the NIH GenBank biological database and the widely used BLAST sequence alignment tool. After a brief discussion of three-dimensional protein structure, he returns to sequence extraction and secondary structure prediction.

Tisdall's goal is to boost the beginning programmer into a domain of self-learning. He imparts essential etiquette for the success of programming newbies: use the wealth or resources available, from user documentation to Web site surveys to FAQs to How-To's to news groups and finally to direct personal appeals for help from a senior colleague. A well-plugged-in bioinformatics Perl student will soon discover Bioperl, an open-source effort to bring research-grade bioinformatic tools to the Perl community. Bioperl is described briefly at the end of Tisdall's book and will reportedly be a forthcoming title of its own in the O'Reilly bioinformatics series.

Although he introduces bioinformatics as an academic discipline, Tisdall treats it as a trade throughout his book. He indicates that open questions and computational hard problems exist, but does not describe what they are or how they are being tackled. Ultimately, Tisdall presents bioinformatics as another arrow in a bench scientist's quiver, very much like HPLC, 2D-PAGE, and the various spectroscopies.

As odd as a "bioinformatics-as-tool" book may be to its research proponents, the reduction of bioinformatics to trade status both deflates and vindicates the years of research, as Tisdall's work attests. --Peter Leopold

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Liposomes: A Practical Approach

Liposomes: A Practical Approach Lowest new price: $90.14
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List price: $105.00
Brand: Brand: Oxford Univ Pr

Since the first edition of "Liposomes - A Practical Approach" was published in 1990, Liposome technology has become a highly successful and rapidly developing area of preclinical and clinical research. During the 90's, a number of liposome-based drugs reached the market in the U.S. and Europe and several new aspects of liposome research have been discovered. As a consequence there has been an explosion of new procedures and techniques in the field. Reflecting both the significant changes in the field and the new discoveries, this new edition of Liposomes contains a combination of chapters from the 1st edition which have been significantly updated, and several new chapters.

Each chapter is an outstanding contribution from leading experts in the field, and the book as a whole encompasses all key areas of liposome technology. The first half of the book addresses a number of essential experimental protocols such as the preparation, characterization, and storage of liposomes. Also included are methods for drug encapsulation into liposomes, modification of the liposomal surface to control drug behaviour in biological environments, long-circulating liposomes and the use of cationic liposomes as transfection vectors. The second half of the book discusses specific areas of liposome research and application, such as pH-sensitive liposomes, liposomes for diagnostic imaging, liposomal DNA vaccines, isothermic titration calorimetry of liposomes and vesicular phospholipids gels.

This new edition of Liposomes is an essential tool for all experienced liposomologists and the perfect introduction for researchers new to the field.

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Introduction to Protein Structure

Introduction to Protein Structure Lowest new price: $69.73
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List price: $108.00
Author: Carl Branden
Brand: Brand: Garland Science

Introduction to Protein Structure provides an account of the principles of protein structure, with examples of key proteins in their biological context generously illustrated in full-color to illuminate the structural principles described in the text. The first few chapters introduce the general principles of protein structure both for novices and for non-specialists needing a primer. Subsequent chapters use specific examples of proteins to show how they fulfill a wide variety of biological functions. The book ends with chapters on the experimental approach to determining and predicting protein structure, as well as engineering new proteins to modify their functions.

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Cell Biology: With STUDENT CONSULT Online Access, 2e (Pollard, Cell Biology, with Student Consult Online Access)

Cell Biology: With STUDENT CONSULT Online Access, 2e (Pollard, Cell Biology,  with Student Consult Online Access) Lowest new price: $74.12
Lowest used price: $20.00
List price: $124.00
Author: Thomas D. Pollard MD
Brand: Brand: Saunders

A masterful introduction to the cell biology that you need to know! This critically acclaimed textbook offers you a modern and unique approach to the study of cell biology. It emphasizes that cellular structure, function, and dysfunction ultimately result from specific macromolecular interactions. You'll progress from an explanation of the "hardware" of molecules and cells to an understanding of how these structures function in the organism in both healthy and diseased states. The exquisite art program helps you to better visualize molecular structures.

  • Covers essential concepts in a more efficient, reader-friendly manner than most other texts on this subject.
  • Makes cell biology easier to understand by demonstrating how cellular structure, function, and dysfunction result from specific macromole¬cular interactions.
  • Progresses logically from an explanation of the "hardware" of molecules and cells to an understanding of how these structures function in the organism in both healthy and diseased states.
  • Helps you to visualize molecular structures and functions with over 1500 remarkable full-color illustrations that present physical structures to scale.
  • Explains how molecular and cellular structures evolved in different organisms.
  • Shows how molecular changes lead to the development of diseases through numerous Clinical Examples throughout.
  • Includes STUDENT CONSULT access at no additional charge, enabling you to consult the textbook online, anywhere you go · perform quick searches · add your own notes and bookmarks · follow Integration Links to related bonus content from other STUDENT CONSULT titles-to help you see the connections between diverse disciplines · test your knowledge with multiple-choice review questions · and more!
  • New keystone chapter on the origin and evolution of life on earth probably the best explanation of evolution for cell biologists available!
  • Spectacular new artwork by gifted artist Graham Johnson of the Scripps Research Institute in San Diego. 200 new and 500 revised figures bring his keen insight to Cell Biology illustration and further aid the reader's understanding.
  • New chapters and sections on the most dynamic areas of cell biology - Organelles and membrane traffic by Jennifer Lippincott-Schwartz; RNA processing (including RNAi) by David Tollervey., updates on stem cells and DNA Repair.
  • ,More readable than ever. Improved organization and an accessible new design increase the focus on understanding concepts and mechanisms.

  • New guide to figures featuring specific organisms and specialized cells paired with a list of all of the figures showing these organisms. Permits easy review of cellular and molecular mechanisms.
  • New glossary with one-stop definitions of over 1000 of the most important terms in cell biology.

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Culture of Animal Cells: A Manual of Basic Technique

Culture of Animal Cells: A Manual of Basic Technique Lowest new price: $70.00
Lowest used price: $20.58
List price: $129.95
Author: R. Ian Freshney

The most complete resource on the techniques, equipment,principles, and practices of animal cell culture

Since publication of the previous edition of this benchmark text, numerous groundbreaking advances have occurred in stem cell research, cloning, tissue engineering, and in vitro toxicity testing. These and other developments have been incorporated into this fully revised and expanded Fifth Edition of Culture of Animal Cells. In addition, to answer the needs of the exponential increase in newcomers to cell culture, particularly in the biopharmaceutical industry, a completely new chapter on training in cell culture technology has been introduced.

The most complete resource on the techniques, equipment, principles, and practices of animal cell culture, this text offers a complete background related to growth of animal cells in culture. Beginning with laboratory design, safety, validation and bioethics, then continuing with preparation of media, primary culture and cell lines, through to characterization and authentication, contamination, specialized techniques, and troubleshooting, the coverage includes:
* An all-new section of training exercises, separated into basic, intermediate, and advanced procedures, cross-referenced to the relevant protocols
* New coverage of stem cells, bioethics, validation, cloning, cell signaling, in vitro toxicity testing, and tissue engineering
* An expanded full-color atlas section, with images of primary culture, cell lines, subculture, differentiation, cancer cells and transformation, three-dimensional culture, contamination, and specialized equipment
* Enhanced treatment of troubleshooting, with full cross-referencing to the relevant protocols and sections of text
* Fully updated references
* The clearest, most consistent presentation of step-by-step protocols available
* Numerous diagrams, photographs, tables, and charts
* Detailed and up-to-date information on reagent preparation and sourcing of materials and equipment, including a fully updated list of suppliers and other resources with Web sites

Indispensable for clinical and biopharmaceutical researchers and scientists, students, trainees, and technicians, this landmark text presents the most accessible and comprehensive introduction available to the culture and experimental manipulation of animal cells.

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Biochemical Adaptation: Mechanism and Process in Physiological Evolution

Biochemical Adaptation: Mechanism and Process in Physiological Evolution Lowest new price: $59.97
Lowest used price: $26.93
List price: $70.00
Author: Peter W. Hochachka

The study of biochemical adaption provides fascinating insights into how organisms "work" and how they evolve to sustain physiological function under a vast array of environmental conditions. This book describes how the abilities of organisms to thrive in widely different environments derive from two fundamental classes of biochemical adaptions: modifications of core biochemical processes that allow a common set of physiological functions to be conserved, and "inventions" of new biochemical traits that allow entry into novel habitats. Biochemical Adaptation: Mechanisms and Process in Physiological Evolution asks two primary questions. First, how have the core biochemical systems found in all species been adaptively modified to allow the same fundamental types of physiological processes to be sustained throughout the wide range of habitat conditions found in the biosphere? Second, through what types of genetic and biochemical processes have new physiological functions been fabricated? The primary audience for this book is faculty, senior undergraduates, and graduate students in environmental biology, comparative physiology, and marine biology. Other likely readers include workers in governmental laboratories concerned with environmental issues, medical students interested in some elements of the book, and medical researchers.

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